piracetam and chronic cerebrovascular disorders

Comparative evaluation of psychoactive drugs used in patients with subacute and chronic cerebrovascular disorders

Wasilewski R, Lebiediewa N, Kozlowa E, Wolkow W.

Neurol Neurochir Pol 1981 Jul-Aug;15(4):447-51


The report is based on 315 patients with subacute and chronic cerebral circulatory disturbances caused mostly by atherosclerosis aged 30 to 82 years, treated for 1-6 months. In 90 cases Piracetam was given, 107 received Pyritinol, 77 Piriditol, 41 Centrophenoxine. The patients were allocated randomly to these groups. In the treated patients improvement was achieved in a considerable proportion of cases (44-82%) treated with different drugs. This improvement manifested itself as regression or decreased intensity of neurotic complaints, labyrinthine-cerebellar signs, pyramidal signs, anxiety and fears, improvement of recent memory, attention, psychomotor activity. The best results were obtained with Piracetam, moderately good with Centrophenoxine, Pyritinol, and poor with Piriditol. Drug tolerance was best with Pyritinol, while that of other drugs was slightly worse. The only disquieting symptoms was activation of epileptic seizures in several patients treated with Piracetam or Centrophenoxine. The best way of administration was giving the drugs in two doses in the morning hours and at noon. The authors regard as useful the treatment of patients with subacute and chronic cerebral circulatory failure with psychoenergizing drugs.