piracetam effect on cerebral glucose utilization

Effect of Piracetam on electrocorticogram and local cerebral glucose utilization in the rat.

Grau M, Montero JL, Balasch J.

Gen Pharmacol 1987;18(2):205-11

Abstract

The effect of piracetam on hypoxia-induced alterations of cerebral cortex electrogenesis is studied. The results showed protection. As this anti-hypoxidotic property could be linked to piracetam influence on energy-metabolic processes in the brain, we studied the effect of this nootropic drug on local cerebral glucose utilization (LCGU) by means of a variant of the Sokoloff’s technique. Our results showed that piracetam enhances LCGU. We suggest that both effects, the functional and the metabolic one, are related.