Single-dose piracetam effects on global complexity measures of human spontaneous multichannel EEG.
Kondakor I, Michel CM, Wackermann J,
Koenig T, Tanaka H, Peuvot J, Lehmann D.
The KEY Institute for Brain-Mind Research,
University Hospital of Psychiatry, Zurich, Switzerland.
Int J Psychophysiol 1999 Oct;34(1):81-7
Global complexity of 47-channel resting electroencephalogram (EEG) of healthy young volunteers was studied after intake of a single dose of a nootropic drug piracetam in 12 healthy volunteers. Four treatment levels were used: 2.4, 4.8, 9.6 g piracetam and placebo. Brain electric activity was assessed through Global Dimensional Complexity and Global Omega-Complexity as quantitative measures of the complexity of the trajectory of multi-channel EEG in state space. After oral ingestion (1-1.5 h), both measures showed significant decreases from placebo to 2.4 g piracetam. In addition, Global Dimensional Complexity showed a significant return to placebo values at 9.6 g piracetam. The results indicate that a single dose of piracetam dose-dependently affects the spontaneous EEG in normal volunteers, showing effects at the lowest treatment level. The decreased EEG complexity is interpreted as increased cooperativity of brain functional processes.