The protective effect of piracetam during delivery
Klink F, Grosspietzsch R, von Klitzing L, Oberheuser F.
Fortschr Med 1979 Dec 6;97(46):2163-5
It was evaluated by continuous cardiotocogram-, tcpO2-and EEG-registration sub partu to what extend these parameters are influenced by application of piracetam (10 g i.v./h) to the mother. A group of 26 primigravida between 18 and 23 years of age with normal course of delivery at term was analyzed. Piracetam was applicated to 17 patients in the beginning of cervix dilatation, whereas the other patients got Levulose as a placebo infusion. The results permit the conclusion that piracetam provides a stabilization of cerebral functions with a certain resistence against transient hypoxia during the expulsion period. The EEG-registration demonstrates after application of piracetam an activation of alpha-waves with simultaneous reduction of delta-waves, the CTG shows a reduced quantity of decelerations during the expulsion period. The data obtained by computerization correlate with the Apgar-Index (fetal outcome) after application of piracetam, which was better than 9 in all cases.