Piracetam in myoclonus

Effectiveness of piracetam in cortical myoclonus.

Brown P, Steiger MJ, Thompson PD, Rothwell JC,
Day BL, Salama M, Waegemans T, Marsden CD.

MRC Human Movement and Balance Unit,
Institute of Neurology, London, England.
Mov Disord 1993;8(1):63-8

Abstract

Twenty-one patients with disabling spontaneous, reflex, or action myoclonus due to various causes, who had shown apparent clinical improvement on introduction of piracetam, entered a placebo-controlled double-blind crossover trial of piracetam (2.4-16.8 g daily). All but one patient had electrophysiological evidence of cortical myoclonus. Patients were randomly allocated to a 14-day course of piracetam followed by identical placebo, or placebo followed by piracetam. Nineteen patients received piracetam/placebo in addition to their routine antimyoclonic treatment (carbamazepine, clonazepam, phenytoin, primidone, sodium valproate, or tryptophan plus isocarboxazid, alone or in combination) and two received piracetam/placebo as monotherapy. All patients were rated at the end of each treatment phase using stimulus sensitivity, motor, writing, functional disability, global assessment, and visual analogue scales. Ten of the 21 patients had to be rescued from the placebo phase of the trial because of a severe and intolerable exacerbation of their myoclonus. No patients required rescue from the piracetam phase of the double-blind trial. When the 21 patients were considered together, there was a significant improvement in motor, writing, functional disability, global assessment, and visual analogue scores during treatment with piracetam compared with placebo. The total rating score also improved significantly with piracetam, by a median of 22%. Piracetam, usually in combination with other antimyoclonic drugs, is a useful treatment for myoclonus of cortical origin.

Alzheimer's disease

piracetam and Alzheimer's

piracetam therapy in Alzheimer's

piracetam use in Alzheimer's

piracetam induced changes in Alzheimer's

piracetam effect on Alzheimer's

piracetam reverses hippocampal changes in Alzheimer's

piracetam and Alzheimer's disease

piracetam controlled study on dementia

piracetam effect on senile dementia memory

Alcoholism

piracetam in acute alcohol withdrawal

piracetam alcoholic treatment

piracetam efficacy in chronic alcoholics

piracetam effect on alcoholics

Child birth

piracetam in parturients and newborn infants

piracetam reduced duration of labor

piracetam protective effect during delivery

piracetam concentrations during delivery

Circulatory Disorders

piracetam effectiveness in cerebral arteriosclerosis

piracetam and chronic cerebrovascular disorders

piracetam effect on brain circulation failure

Dyslexia

piracetam learning aid in dyslexia

piracetam in children with dyslexia

piracetam in students with dyslexia

piracetam efficacy in dyslexic reading and writing disorders

piracetam verbal effect in dyslexic boys

piracetam improves reading in dyslexia

Head injury

piracetam and concussion

piracetam effect on consciousness due to head injury

piracetam protection in brain injury

piracetam use in severe brain injury

Hearing loss

piracetam use in sudden deafness

piracetam sudden hearing loss treatment

piracetam in tinnitus and sudden deafness

piracetam treatment of sudden deafness

Heart Disease

piracetam effects on arterial hypertension

piracetam effect on elderly coronary heart disease

piracetam in chronic ischemic heart disease

piracetam in ischemic heart disease

piracetam in myocardial infarct patients

Mental Performance

piracetam improved mental performance

piracetam and nootropics

piracetam in patients with mental decline�

piracetam effects on cognitive functions

piracetam improves memory

piracetam efficacy in cognitive impairment

piracetam memory impairment trial

piracetam and EEG of boys with learning disorders

piracetam effect on adolescent brain function

piracetam effects on human EEG

piracetam on change in brain functional state

piracetam effects on brain functions

piracetam in elderly cerebral impairment

piracetam in cerebral impairment

Stroke

piracetam in secondary stroke prophylaxis

piracetam improves blood flow of post-stroke patients

piracetam improves aphasia in acute stroke

piracetam in the treatment of acute stroke

piracetam evaluation in acute stroke

piracetam in stroke-unduced Aphasia

piracetam treatment in ischemic stroke

piracetam treatment of patients with an ischemic stroke

piracetam acute stroke study

piracetam effect on post-stroke recovery

piracetam improvement in Stroke

piracetam adjuvant to language therapy for aphasia

Vertigo

piracetam treatment for vertigo

piracetam is effective in vertigo

piracetam effect in 55 vertigo patients

piracetam subjective improvement in vertigo

piracetam significantly reduced vertigo symptoms

Myoclonus

piracetam and reduction of myoclonus

piracetam relieves symptoms in myoclonus epilepsy

piracetam in cortical myoclonus

piracetam and progressive myoclonus epilepsy

piracetam in patients with myoclonus

piracetam in progressive myoclonus epilepsy

piracetam promising results in myoclonus epilepsy

piracetam long-term efficacy in myoclonus epilepsy

piracetam beneficial use for severe myoclonus epilepsy

piracetam beneficial effect on post-ischaemic myoclonus

Raynaud's

piracetam treatment of Raynaud's

piracetam evidence for its anti-platelet effect in Raynaud's

piracetam platelet anti-aggregant properties

Sickle Cell disease

piracetam treatment of children with sickle cell disease

piracetam improves sickle cell deformability

piracetam crises management of sickle cell disease

Misc.

piracetam mechanism of action

piracetam elevates cholinergic receptor density

piracetam cholinergic receptor function in mice

piracetam effects on schizophrenia

piracetam effect on cerebral glucose utilization

piracetam improved driving in elderly motorists

piracetam unique mode of action

piracetam study age-related memory disorders

piracetam psychological treatment

piracetam and aging

piracetam and vigilance

piracetam versus acetylcholinesterase inhibitors

piracetam effects on arterial hypertension

piracetam in cerebral palsy

piracetam auxiliary treatment of cerebral palsy

piracetam interaction in the motor cortex

piracetam effect on consciousness after neurosurgery

piracetam effect on cerebral infarction

piracetam improves cognitive deficits in early Parkinsonism

piracetam therapy in recurrent duodenal ulcer

piracetam efficacy in recurrence of duodenal ulcer

piracetam efficacy in breath-holding spells

piracetam treatment of migraine

piracetam treatment of soft tissue rheumatism�

piracetam effect on intellectually deficient children

piracetam effect on neuroleptic-induced side effects

piracetam improved school-performance in legasthenia

piracetam cerebroprotective effect in brain edema

piracetam protective effect during delivery